Luigi Frigerio

331 - Triptorelin Administration in the luteal Phase Improves the outcome of art cycles.

F.M. Fusi, M. Arnoldi, C. Bosisio, L. Zanga, L. Frigerio.
Department of OB/GYN, Ospedale Papa Giovanni XXIII, Bergamo, BG Italy; Università Milano Bicocca, Mi, Italy.
Objective: the objective of this study was evaluate the impact of triptorelin administration in the luteal phase on the out come of Art cycles. Design: 415 women were enrolled in this study. The underwent an Art for either tubal or idiopathic factor of for mild or moderate male factor.They were divided into two stimulation protocols. 263 received a classic long stimulation protocol.132 received a short antagonist protocol. Embryo transfer was performed on D2, and administration of micronized progesterone, 600 mg/day, started on D1.both groups were then divided for the luteal phase in two homogeneous groups, who received only progesterone, or who had 5 injections of 0,1 mg triptorelin, one every other day. Pregnancy rate, ongoing pregnanct rate and implantation rate were compared.Materials AND METHODS: Group 1:263 womwn whose ovulation induction was performed with a long protocol. 131 during the luteal phase received triptorelin in addition to progesterone, 132 received only progesterone. Group 2:132 women were induced using a short protocol with antagonists. 76 during the luteal phase received triptorelin in addition to progesterone, 76 received only progesterone. CONCLUSION: triptorelin improved the results in both groups of ovulation induction, although the only statistically significant difference was found in the long protocol group. The positive effect of triptorelin might be due a flare pituitary that stimulates corpora lutea, or to a direct effect on the decidua or embryo. In any case, the use of triptorelin should be considered in the clinical use for the supplementation of luteal phase.